What question did this study set out to answer?

To identify the range of safe airway pressures capable of fully recruiting atelectatic lung tissue without causing barotrauma in an ex-vivo rabbit model.

July 13, 2013European Journal of Anaesthesiology

Pressure safety range of barotrauma with lung recruitment manoeuvres

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To identify the range of safe airway pressures capable of fully recruiting atelectatic lung tissue without causing barotrauma in an ex-vivo rabbit model.
Prospective, randomized experimental study conducted in 14 healthy young New Zealand rabbits (12 weeks of age) with opened pleural cavities.
Lungs were randomized to either a PEEP-20 strategy (PEEP titrated to 20 cmH2O) or a PEEP-50 strategy (PEEP titrated to 50 cmH2O) at a fixed driving pressure of 15 cmH2O, after which driving pressure was escalated by 5-cmH2O increments until macroscopic barotrauma occurred.
Open lung maximal inspiratory pressure (MIP) was 23.6 ± 3.8 cmH2O in the PEEP-50 group and 23.3 ± 4.1 cmH2O in the PEEP-20 group (P = 0.91).
Barotrauma MIP was significantly higher in the PEEP-50 group at 65.7 ± 3.4 cmH2O compared to 56.7 ± 5.2 cmH2O in the PEEP-20 group (P = 0.003), yielding a wider pressure safety range of 42.1 ± 3.9 versus 33.3 ± 8.7 cmH2O (P = 0.035).

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Implication

Randomized experimental study demonstrates a wider pressure safety margin against barotrauma with higher PEEP recruitment in rabbit lungs, suggesting greater safety with higher baseline PEEP.

Cite This Study

Fernandez et al. (2013) studied this question.

synapsesocial.com/papers/6aa7fdb0394eb5723c8dad87 https://doi.org/10.1097/eja.0b013e3283607875

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Implication

Randomized experimental study demonstrates a wider pressure safety margin against barotrauma with higher PEEP recruitment in rabbit lungs, suggesting greater safety with higher baseline PEEP.

Pressure safety range of barotrauma with lung recruitment manoeuvres

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Discussion

Implication

Cite This Study

Pressure safety range of barotrauma with lung recruitment manoeuvres

Key Points

Discussion

Implication

Cite This Study

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