In Vivo Incorporation of 69Fe into Nonhem Iron and Hemoglobin of Red Blood Cells

Falbe‐Hansen, I. and K. Lothe. In vivo incorporation of 50Fe into nonhem iron and hemoglobin of red blood cells. Acta physiol. scand. 1962. 54. 97–104. – The incorporation of 59Fe into nonhem iron and hemoglobin iron of circulating erythrocytes has been followed in rabbits. The experiments indicate that nonhem iron represents an intermediate step in the passage of iron from transferrin to hemoglobin. Nonhem iron is also present in the later stages of erythrocyte life, but in a metabolically inactive state. By electrophoresis three iron‐containing fractions have been separated, one of which is radioactive. It is suggested that this radioactive fraction represents a shortlived step in the iron transport system. One of the inacative fractions has an electrophoretic migration velocity similar to that of ferritin.