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Hydrophobic PEG: Chemical-shift-perturbation mapping reveals an interaction between poly(ethylene glycol) and the hydrophobic surface surrounding the exposed haem edge of cytochrome c. This suggests that PEG might be a poor choice of crowding agent in protein interaction studies. In contrast, cytochrome c can be embedded in agarose gels with little effect on the NMR spectrum.
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Crowley et al. (2008) studied this question.
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