In vitro studies of controlled release from chitosan/gelatin hybrid membranes were carried out using drugs of different molecular weight. It was found that release of urea, 5-fluorouracil (5-Fu), sodium benzoate, sodium salicylate, sodium mandelate, and sulfacetamide sodium followed zero-order kinetics after a short time lag. Variation of the diffusion coefficient, permeation coefficient, and degree of hydration with crosslinking and varying weight percent of gelatin in membrane matrices were studied in detail by using 5-Fu as a model drug. The diffusion coefficient and permeation coefficient of 5-Fu are dependent on the degree of hydration of the swollen membrane. The transport process of drug molecules in the hydrogel membrane is presumed to be predominantly of the pore mechanism.
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Cheng et al. (1998) studied this question.