Key result
Low-frequency variants near GGCT are linked to ~46% lower CAD risk in type 2 diabetes.
Why the study?
Low-frequency variants in genes involved in glutamic acid metabolism and the γ-glutamyl cycle may influence coronary artery disease risk in individuals with type 2 diabetes, but their associations were not fully characterized.
Are low-frequency variants in glutamic acid metabolism genes associated with altered risk of coronary artery disease in patients with type 2 diabetes?
Comparison
Presence vs absence of low-frequency variants in genes involved in glutamic acid metabolism and the γ-glutamyl cycle
Design
Case-control genetic association study
Authors
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Low-frequency genetic variants in glutamic acid metabolism and the γ-glutamyl cycle are associated with altered risk of coronary artery disease in individuals with type 2 diabetes, highlighting a potential mechanistic pathway.
Case-Control (n=3,526)
Are low-frequency variants in glutamic acid metabolism genes associated with altered risk of coronary artery disease in patients with type 2 diabetes?
Odds Ratio: 0.54
p-value: p=2.5 × 10^-4
Low-frequency genetic variants in glutamic acid metabolism and the γ-glutamyl cycle are associated with altered risk of coronary artery disease in individuals with type 2 diabetes, highlighting a potential mechanistic pathway.
Giuffrida et al. (2024) conducted a case-control in Coronary artery disease in type 2 diabetes (n=3,526). Low-frequency variants in GLUL, GGCT, and DPEP2 genes vs. Reference alleles was evaluated on Coronary artery disease status (OR 0.54, p=2.5 × 10^-4). Low-frequency variants flanking the GGCT (OR 0.54, p=2.5×10^-4), DPEP2 (OR 0.61), and GLUL (OR 1.84) genes were significantly associated with coronary artery disease risk in type 2 diabetes.
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