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The lucanthone (“miracil”) compound 27T51, which was found to be active against Schistosoma mansoni in baboons, proved to be unsuitable for human treatment. A single dose caused severe nerve deafness and repeated doses were considered impracticable. Single doses at the rate of 12.5 mg./kg. had no effect on Schistosoma haematobium infections in man.
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J. Newsome (1954) studied this question.
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