Phenylephrine Vs. Norepinephrine on the Renin–Angiotensin–Aldosterone System and Postoperative Complications in Acute Abdomen Emergency Surgery: A Randomized Controlled Trial

Figures

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  Figure 1.. Study flow diagram.

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  Figure 2.. Levels and changes of components of the renin–angiotensin–aldosterone system. Median (interquartile range) levels of plasma renin, angiotensin II, aldosterone concentration, angiotensin-converting enzyme 2 activity, and aldosterone: renin, angiotensin: renin ratio at baseline, immediate postoperative period (T1), and 24 hours postoperatively (T2).

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  Figure 3.. Association between baseline RAAS levels and drug dosage. Total cumulative study drug in norepinephrine equivalent dose, plotted by randomization group, versus ascending quartiles of plasma renin, angiotensin II, aldosterone concentration, and angiotensin-converting enzyme 2 (ACE2) activity (each component level was arranged individually in ascending order, and subsequently divided into four equal quartiles. The lowest 25% are categorized as quartile 1, the next 25–50% as quartile 2, the 50–75% range as quartile 3, and the highest 25% as quartile 4.