Key result
Post-op albumin drop ≥10% at 6 hours linked to ~326% higher surgical complication risk.
Why the study?
Many factors help predict post-surgical outcomes; this study evaluated preoperative and postoperative albumin levels and their difference for predicting clinical outcomes after surgery.
Does post-operative serum albumin drop predict clinical outcomes in patients undergoing abdominal surgery?
Observational (n=110)
No
Does post-operative serum albumin drop predict clinical outcomes in patients undergoing abdominal surgery?
Absolute Event Rate: 80.6% vs 18.9%
p-value: p=<0.0001
A post-operative drop in serum albumin of >10% at 6 hours or >15% at POD-1 is strongly associated with surgical complications in patients undergoing abdominal surgery.
May flag high-risk abdominal surgery patients early; hypothesis-generating and requires prospective validation before practice change.
Background: Surgical interventions have become part and parcel of an individual’s life. The average number of surgeries that a person undergoes in their lifetime is 9.2 (3.4 inpatient operations, 2.6 outpatient operations, and 3.2 non-operating room invasive procedures). So it is important to make sure that the patient undergoes surgery smoothly and gets out of hospital well at early days. There are many factors that help to predict the outcome post surgeries, in this study we have used albumin (pre and post op) and its difference for predicting the clinical outcome.Methods: 80 patients who are undergoing abdominal (intra-peritoneal) surgeries from October 2019 to December 2020 was studied. Serum albumin was estimated by Randox albumin assay method. Serum albumin level was obtained pre-operatively, post-op after 6 hours and on POD-1 and their difference is found and compared with clinical outcome using Clavien-Dindo classification.Results: It was observed that 81.5% (22 out of 27) of patients with albumin drop more than 10% by 6 hours post operatively are likely to develop complications of surgery. It was observed that 89% (16 out of 18) of patients with albumin drop more than 15% by POD1 are likely to develop complications of surgery.Conclusions: In our study raised serum albumin drop post-operatively was associated with complications and so it can be concluded that serum albumin may be used as a marker for predicting the clinical outcome of the patients undergoing surgery.
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J. et al. (2022) conducted an observational in Abdominal (intra-peritoneal) surgery (n=110). Post-operative serum albumin drop ≥10% at 6 hours vs. Post-operative serum albumin drop <10% at 6 hours was evaluated on Development of post-surgical complications (Clavien-Dindo classification) (p=<0.0001). A post-operative serum albumin drop of ≥10% at 6 hours was significantly associated with a higher rate of surgical complications compared to a drop of <10% (80.6% vs 18.9%, p<0.0001).
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