Isocyanide‐Based Five‐Component Synthesis of 2‐Aryl‐2‐(2,3,4,5‐tetrahydro‐2,4‐dioxo‐1H‐1,5‐benzodiazepin‐3‐yl)acetamides (=α‐Aryl‐2,3,4,5‐tetrahydro‐2,4‐dioxo‐1H‐1,5‐benzodiazepine‐3‐acetamides)

An efficient and simple method for the synthesis of new 2‐aryl‐2‐(2,3,4,5‐tetrahydro‐2,4‐dioxo‐1H‐1,5‐benzodiazepin‐3‐yl)acetamides (=α‐aryl‐2,3,4,5‐tetrahydro‐2,4‐dioxo‐1H‐1,5‐benzodiazepine‐3‐acetamides) by a five‐component condensation reaction of benzene‐1,2‐diamine (1), Meldrum's acid (2), aldehydes 3, isocyanides 4, and H2O in CH2Cl2 at room temperature is reported (Table 1 and Scheme 2). These products were evaluated in vitro for their antibacterial activities (Table 2).