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The purpose of the current study was to prepare Methotrexate (MTX) loaded Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles (NPs) and investigates their toxicity effect on human glioblastoma cells. The influence of different experimental parameters including polymer concentration, Poly Vinyl Alcohol (PVA) concentration in the external phase and drug concentration on the particle size was evaluated.
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Farid et al. (2017) studied this question.
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