Key result
Adding PDW to preoperative D-dimer improves postoperative DVT prediction, yielding an AUC of ~0.78.
Why the study?
DVT is associated with severe morbidity and mortality in cancer, prompting an investigation into whether combining D-dimer with platelet distribution width could better predict postoperative DVT in patients with cervical carcinoma.
Does the combination of preoperative D-dimer and PDW improve the prediction of postoperative DVT in patients with cervical carcinoma?
Population
198 consecutive cervical carcinoma patients without preoperative DVT
Comparison
Combination of preoperative D-dimer and PDW vs D-dimer alone
Design
Cohort study
Follow-up
Median period of 12 months
Authors
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May aid postoperative DVT risk stratification in cervical carcinoma; hypothesis-generating and requires prospective validation.
Cohort (n=198)
No
Does the combination of preoperative D-dimer and PDW improve the prediction of postoperative DVT in patients with cervical carcinoma?
Absolute Event Rate: 0.777% vs 0.628%
p-value: p=<0.001
The combination of preoperative D-dimer and PDW significantly improves the prediction of postoperative DVT risk in patients with cervical carcinoma compared to D-dimer alone.
Li et al. (2019) conducted a cohort in Cervical carcinoma (n=198). Combination of preoperative D-dimer and Platelet Distribution Width (PDW) vs. D-dimer alone was evaluated on Prediction of postoperative deep venous thrombosis (Area under the ROC curve) (95% CI 0.712 to 0.833, p=<0.001). The combination of preoperative D-dimer and platelet distribution width (PDW) significantly improved the prediction of postoperative deep venous thrombosis compared to D-dimer alone, increasing the AUC from 0.628 to 0.777.
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