PURPOSE OF REVIEW: In the past, carcinomatosis from colorectal cancer was determined to be a lethal condition with a short survival. RECENT FINDINGS: A new treatment strategy starts with cytoreductive surgery in an attempt to remove all visible evidence of cancer implants. Then, chemotherapy is used in the operating room with moderate hyperthermia (41-43 degrees C) in an attempt to eradicate microscopic residual disease. Multiple phase II, a phase III, and a multi-institutional phase II study of 503 patients showed that approximately one-third of these patients can survive long term. SUMMARY: The expansion of treatment options, including cytoreductive surgery followed by chemotherapy with hyperthermia, to a larger number of patients is appropriate.
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Paul H. Sugarbaker (2005) studied this question.
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