A series of synthetic phosphatidylserines containing saturated fatty ester residues (C6 to C18) has been synthesized. These compounds have been studied in combination with natural phosphatidylethanolamine in the two-stage thromboplastin-generation test. The observed activity of these mixtures depends on the fatty acid chain length of the phosphatidylserine. These variations are accounted for in terms of the micelle theory of thromboplastic activity.
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Grisdale et al. (1965) studied this question.