What is the clinical evidence from this study?

Study design: Observational. Population: Familial hyperaldosteronism type II. Intervention: Chromosome 7p22 locus. Primary outcome: Combined multipoint logarithm of odds (LOD) score for linkage at 7p22 (LOD score 5.22).

What does this research mean for the field?

Familial hyperaldosteronism type II is linked to chromosome 7p22 across multiple geographically diverse populations with a combined multipoint LOD score of 5.22. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 2008Journal of Hypertension

Further evidence for linkage of familial hyperaldosteronism type II at chromosome 7p22 in Italian as well as Australian and South American families

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Key result

Genetic analysis strongly links familial hyperaldosteronism type II to chromosome 7p22.

LOD score 5.22

Population

Five families with familial hyperaldosteronism type II, including affected and unaffected individuals.

Design

Other

Authors

NSNorlela SukorHospital Kuala Lumpur PMPaolo MulateroPreventive Cardiology RGRichard D. GordonGeneral Motors (United States)

Discussion

Member takes

Implication

Does not change FH-II management; confirms 7p22 linkage and leaves open causative variant identification.

Study Design

Type

Observational

Multicenter

Yes

Structured PICO

Population

Members of five families (two Italian, two Australian, one South American) with familial hyperaldosteronism type II evaluated for genetic linkage to chromosome 7p22.

Exposure

Genotype analysis using seven closely spaced microsatellite markers at chromosome 7p22.

Outcome

Multipoint logarithm of odds (LOD) score to assess linkage with familial hyperaldosteronism type II at chromosome 7p22.surrogate

Main Result

Effect estimate: LOD score 5.22

This study confirms the linkage of familial hyperaldosteronism type II to chromosome 7p22 across multiple geographical regions, highlighting its importance for identifying the causative mutation.

Cite This Study

Sukor et al. (2008) conducted an observational in Familial hyperaldosteronism type II. Chromosome 7p22 locus was evaluated on Combined multipoint logarithm of odds (LOD) score for linkage at 7p22 (LOD score 5.22). Genetic analysis of five families with familial hyperaldosteronism type II demonstrated highly significant linkage to chromosome 7p22 with a combined multipoint LOD score of 5.22.

synapsesocial.com/papers/6aa830311a27575409ae5ea2 https://doi.org/10.1097/hjh.0b013e3283028352

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Further evidence for linkage of familial hyperaldosteronism type II at chromosome 7p22 in Italian as well as Australian and South American families

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Further evidence for linkage of familial hyperaldosteronism type II at chromosome 7p22 in Italian as well as Australian and South American families

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider