Key result
Right ventricular restrictive physiology shows no association with maximum heart rate or metabolic equivalents.
Why the study?
The effect of right ventricular restrictive physiology on exercise capacity and arrhythmogenesis after correction of tetralogy of Fallot was unclear.
Does right ventricular restrictive physiology affect exercise capacity and arrhythmogenesis in pediatric patients after correction of tetralogy of Fallot?
Cohort (n=80)
Does right ventricular restrictive physiology affect exercise capacity and arrhythmogenesis in pediatric patients after correction of tetralogy of Fallot?
Right ventricular restrictive physiology at 6 months post-correction of tetralogy of Fallot does not significantly impact exercise capacity or arrhythmogenesis, though both groups exhibit chronotropic incompetence compared to normal children.
The effect of right ventricular restrictive physiology on exercise capacity and arrhythmogenesis after correction of tetralogy of Fallot was assessed in 80 patients aged 7.9 +/- 3.6 years. Right ventricular restrictive physiology was defined as the presence of an A wave across the pulmonary artery on 2-dimensional echocardiography. At the 6 month follow-up, 52 patients had restrictive physiology (group 1). A transannular patch was used in 36 patients in group 1 (62%) and in 19 (86%) of the 28 patients without restrictive physiology (group 2). Maximum heart rate attained (69% vs. 77%), maximum predicted heart rate (211 +/- 12.6 vs. 226 +/- 24.2 beats x min(-1)), and metabolic equivalents (7.6 +/- 3.2 vs. 8.1 +/- 2.6) were higher in group 2, but not significantly. The chronotropic index was similar in both groups. In group 1, 14% of patients presented with ventricular premature complexes at 6 months. No effect on exercise capacity and arrhythmogenesis could be attributed to restrictive physiology, but both groups had chronotropic incompetence compared to normal children.
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Rathore et al. (2006) conducted a cohort in Tetralogy of Fallot (n=80). Right ventricular restrictive physiology vs. Without restrictive physiology was evaluated on Maximum heart rate attained. Right ventricular restrictive physiology did not significantly affect maximum heart rate attained (69% vs 77%) or metabolic equivalents compared to those without restrictive physiology.
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