Key result
Arthritis is linked to ~73% higher serum Lipocalin-2 levels that correlate with oxidative stress markers.
Why the study?
Lipocalin-2 is linked to skeletal muscle regeneration, but its role in arthritis and its relationship with oxidative and antioxidative factors remain unclear.
Are serum LCN2 levels and oxidative/antioxidative factors altered in patients with arthritis compared to healthy controls?
Case-Control (n=125)
No
Are serum LCN2 levels and oxidative/antioxidative factors altered in patients with arthritis compared to healthy controls?
LCN2 levels and oxidative stress markers are significantly elevated in arthritis patients, suggesting a potential role in iron-related oxidative stress damage.
LCN2 levels may associate with oxidative imbalance in arthritis; leaves open any diagnostic or therapeutic role pending prospective validation.
Background: Lipocalin-2 (LCN2) is a protein that has been associated with skeletal muscle regeneration, but details regarding its role in Arthritis remain unclear.The aim of the current study was to investigate LCN2 levels of Arthritis patients and its relationship with oxidative and antioxidative factors Methods:The study includes (125) blood samples of persons aged 20-65 years were divided into a control group (apparently healthy) consisting of 55 samples [31female, 24 males] and a Patient group consisting of 70 samples [37female, 33 males] who were attending the bone diseases consultation unit at the Ibn Sina Teaching Hospital in Mosul, Iraq.Venous blood samples (10 ml) were collected after overnight fasting.To conduct Clinical analyses: Serum LCN2 level was determined by ELISA, also Malonaldehyde, glutathione, vitamin E, vitamin C, peroxy nitrite, peroxidase, and aryl esterase were estimatedResults: The findings revealed a significant increase in the levels of LCN2 in Arthritis compared to the control group and there was a significant decrease in the concentration of vitamin C, glutathione, vitamin E and the activity of the arylesterase in serum of patients with arthritis compared with the control group.Also, a significant increase in the activity of peroxidase, concentration of peroxynitrite and malondialdehyde for patients than a control group Conclusion: These findings imply that LCN2 may play a substantial role in iron-related oxidative stress damage in arthritis.Thus a therapeutic candidate target for treatment.
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Saadon et al. (2023) conducted a case-control in Arthritis (n=125). Arthritis vs. Healthy controls was evaluated on Serum Lipocalin-2 (LCN2) concentration (p=≤0.001). Patients with arthritis had significantly higher serum Lipocalin-2 concentrations compared to healthy controls (124.38 vs 72.01 ng/ml, p≤0.001), which correlated with markers of oxidative stress.
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