Moderator's view: Biomarkers in glomerular diseases--translated into patient care or lost in translation?

This is the authors' abstract. We don't add key points for this paper.

kidney is not enough to induce recurrent disease-more than genetic risk is needed.The study of Sadowski et al., reporting that a single gene causes steroid-resistant nephrotic syndrome in 30% of children and young adults, owns its success to the fact that patients had an excellent 'marker' for a genetic disease: a positive family history.However, mutations in adult patients without family history are extremely rare and screening is not recommended.We agree with Doctors Mariani and Kretzler regarding the 'paucity of robust data from RTC to support treatment recommendations' in glomerular diseases.However, this is in great part due to the lack of interest from the funding agencies in conducting translational research.Instead, significant funding is invested in sophisticated research far away from the bedside, thus delaying clinician access to therapeutical approaches that could help patients today.