Key result
Fatal late-onset malignant hyperthermia develops 21 hours after sevoflurane anesthesia despite dantrolene treatment.
Why the study?
Malignant hyperthermia is a rare and potentially fatal complication of anesthesia that can occur postoperatively, especially after operations involving ischaemia-reperfusion injuries.
Case Report (n=1)
Highlights the risk of fatal late-onset malignant hyperthermia in pediatric patients undergoing operations involving ischemia-reperfusion injuries.
Case Report / Olgu Sunumu Malignant hyperthermia (MH) is a rare and potentially life threatening fatal complication of anaesthesia.We present a 2-year-old boy with late onset MH after colon interposition to replace the oesophagus under sevoflurane anaesthesia.The patient was treated with intravenous dantrolene sodium as well as cooling and controlled ventilation.Despite treatment, the patient developed cardiopulmonary arrest at 21 hours after the operation and died.It should be kept in mind that post-operative MH may develop during these types of operations with ischaemia-reperfusion injuries.Keywords: Malignant hyperthermia, general anaesthesia, postoperative hyperthermia, colon interposition Malign hipertermi (MH) nadir, hayatı tehdit eden ve ölümcül olabilecek bir anestezi komplikasyonudur.Biz iki yaşında erkek çocukta sevofluran anestezisi altında özafagus yerine kolon interpozisyonu sonrası geç başlangıçlı MH sunduk.Hasta intravenöz dantrolen sodyum, soğutma ve kontrollü solunumla tedavi edildi.Tedaviye rağmen girişimden 21 saat sonra hastada kardiyopulmoner arrest gelişti ve hasta exitus kabul edildi.İskemi reperfüzyon hasarıyla ilgili bu tür operasyonlarda postoperatif MH nin gelişebileceği akılda tutulmalıdır.
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Şahin et al. (2015) conducted a case report in Malignant hyperthermia (n=1). Sevoflurane anaesthesia and colon interposition was evaluated on Cardiopulmonary arrest and death. A 2-year-old boy developed fatal late-onset malignant hyperthermia 21 hours after colon interposition under sevoflurane anesthesia despite treatment with dantrolene sodium.
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