Key result
Zinc gluconate and nedocromil sodium reduce cold-induced performance impairments such as choice reaction time deficits.
Why the study?
Do zinc gluconate and nedocromil sodium reduce performance impairments induced by the common cold in volunteers?
Do zinc gluconate and nedocromil sodium reduce performance impairments induced by the common cold in volunteers?
Zinc gluconate and nedocromil sodium may reduce performance deficits associated with the common cold, potentially via changes in trigeminal stimulation.
May reduce cold-induced performance deficits in volunteers; leaves open translation to clinical populations or practice.
Two studies are reported on the effects of drugs on the performance impairments induced by experimentally- produced colds. The first study examined the effects of zinc gluconate on choice reaction time, and showed that the zinc removed the cold-induced performance impairment. The second experiment used nedocromil sodium and, again, the drug was effective in reducing the drop in performance observed in volunteers with colds. While the precise mode of action of these compounds is unclear it is speculated that one mechanism involves changes in trigeminal stimulation, and this could be responsible for both the clinical efficacy and CNS effects of these drugs.
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Smith et al. (1991) studied Experimentally-produced common cold. Zinc gluconate and nedocromil sodium was evaluated on Performance impairments (e.g., choice reaction time). Zinc gluconate and nedocromil sodium effectively reduced performance impairments, such as choice reaction time deficits, induced by experimentally-produced colds.
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