Rifampicin-resistant mutations were induced in Pseudomonas putida A11rUV growing in soil containing 9,10-dimethyl-1,2-benzanthracene and benzo[a]pyrene. Aging of the compounds for 7 d caused a marked decrease in the mutation rates, and the number of mutants was further reduced after 15 d of aging. Longer persistence of the compound in soil did not further diminish the number of mutants. Vigorous solvent extraction showed that the concentration of the compounds had not diminished with the marked decline in genotoxicity. The data demonstrate that genotoxicity of such compounds aged in soil declines with little or no loss of the compound.
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Alexander et al. (1999) studied this question.
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