Answers are grounded in this paper and cite their sources.
Because of their easy availability and their relative chemical stability, urea, formic acid, and glycine might have played a role in the assembly process of nucleobases. In this paper, a short reaction path is described to prepare hypoxanthine starting from the above mentioned precursors. The formation of hypoxanthine has been verified by high-resolution mass spectrometry with the 15N-labelled urea as starting material, and HPLC analysis. The yield of this condensation reaction has been determined spectrophotometrically.
No takes yet. Share an insight, caveat, or question.
Lagoja et al. (2004) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: