Lung Purpura and Nephritis (Goodpasture's Syndrome) Complicated by the Nephrotic Syndrome

Article1 November 1965Lung Purpura and Nephritis (Goodpasture's Syndrome) Complicated by the Nephrotic SyndromeV. R. BLOOM, B.M., D. J. WAYNE, B.M., O. M. WRONG, D.M.V. R. BLOOM, B.M.Search for more papers by this author, D. J. WAYNE, B.M.Search for more papers by this author, O. M. WRONG, D.M.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-572 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Association of a Hemorrhagic lung disorder with glomerulonephritis was described by Goodpasture in 1919 (1). The term "Goodpasture's syndrome" was coined by Stanton and Tange (2) when they reported nine other cases with this association, but Rusby and Wilson (3) preferred the term "lung purpura with nephritis" for their five cases.The typical clinical picture is of a young adult male with a rapidly fatal glomerulitis that has many of the features of the 'subacute course' of glomerulonephritis described by Volhard and Fahr (4) and that is either preceded or complicated by repeated and profuse hemoptysis. The following five...References1. GOODPASTURE EW: The significance of certain pulmonary lesions in relation to the etiology of influenza. Amer. J. Med. Sci. 158: 863, 1919. CrossrefGoogle Scholar2. STANTONTANGE MCJD: Goodpasture's syndrome. (Pulmonary haemorrhage associated with glomerulonephritis.) Aust. Ann. Med. 7: 132, 1958. CrossrefMedlineGoogle Scholar3. RUSBYWILSON NLC: Lung purpura with nephritis. Quart. J. Med. 29: 501, 1960. MedlineGoogle Scholar4. 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CRUICKSHANKPARKER JGRA: Pulmonary haemosiderosis with severe renal lesions. Thorax 16: 22, 1961. CrossrefMedlineGoogle Scholar18. GHOSE RR: Goodpasture's syndrome. Brit. Med. J. 1: 262, 1962. CrossrefGoogle Scholar19. DE GOWINODAEVANS RLYRH: Nephritis and lung hemorrhage. Arch. Intern. Med. (Chicago) 111: 16, 1963. CrossrefMedlineGoogle Scholar20. AZENCLATANOFF EADV: Prolonged survival in Goodpasture's syndrome. Arch. Intern. Med. (Chicago) 114: 453, 1964. CrossrefMedlineGoogle Scholar21. SALTZMANWESTCHOMET PWMB: Pulmonary hemosiderosis and glomerulonephritis. Ann. Intern. Med. 56: 409, 1962. LinkGoogle Scholar22. PEARSPICKERING MAGW: Changes in the fundus oculi after haemorrhage. Quart. J. Med. 29: 153, 1960. MedlineGoogle Scholar23. FAIRLEYKINCAID-SMITH KGP: Goodpasture's syndrome. Brit. Med. J. 2: 1646, 1961. CrossrefGoogle Scholar24. SCADDING JG: Discussion on the lungs as an index of systemic disease. Proc. Roy. Soc. Med. 51: 649, 1958. CrossrefMedlineGoogle Scholar25. OLDHAM E: Goodpasture's syndrome. New Zeal. Med. J. 58: 378, 1959. MedlineGoogle Scholar26. SOERGELSOMMERS KHSC: Idiopathic pulmonary hemosiderosis and related syndromes. Amer. J. Med. 32: 499, 1962. CrossrefGoogle Scholar27. LEFFFAZEKAS ILG: Hemorrhagic and interstitial pneumonitis with nephritis. Ann. Intern. Med. 56: 296, 1962. LinkGoogle Scholar28. RANDALLGLAZIERLIGGETT REJSM: Nephritis with lung hemorrhage. Lancet 1: 499, 1963. CrossrefMedlineGoogle Scholar29. CANFIELDDAVIESHERMAN CJTERH: Hemorrhagic pulmonary renal syndrome. New Eng. J. Med. 268: 230, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: London,From the Departments of Medicine, Central Middlesex and Hammersmith Hospitals, London, England.Requests for reprints should be addressed to O. M. Wrong, D.M., Hammersmith Hospital, DuCane Rd., London, W.12, England. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIronKrankheiten der Atemwege und des MediastinumsStudy of haemostasis in nephropathies associated with pulmonary haemorrhageRemission in Goodpasture's syndrome: report of two patients treated by immunosuppression and review of the literatureGoodpasture's SyndromeGoodpasture's syndromeGLOMERULONEPHRITIS WITH INITIAL LUNG PURPURA (GOODPASTURE'S SYNDROME)Goodpasture's Syndrome Cessation of Pulmonary Hemorrhage After Bilateral NephrectomyR. K. MADDOCK JR., M.D., L. E. STEVENS, M.D., K. REEMTSMA, M.D., H. A. BLOOMER, M.D., F.A.C.P.Treatment of Chronic Renal Failure 1 November 1965Volume 63, Issue 5Page: 752-759KeywordsAnemiaGlomerulonephritisHospital medicineLungsNephritisSteroid therapyThrombosisYoung adults Issue Published: 1 November 1965 PDF DownloadLoading ...