Light, zinc-finger nuclease, action: Using unnatural amino acid mutagenesis, a light-activated zinc-finger nuclease enzyme was engineered through incorporation of a photocaged tyrosine residue at a DNA–protein interface. The caged zinc-finger nuclease was completely inactive until irradiated with UV light, thus enabling photochemical control of sequence specific gene editing in mammalian cells (see picture).
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Chou et al. (2011) studied this question.
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