Key result
Device therapy for life-threatening ventricular arrhythmias requires careful selection and concomitant antiarrhythmics.
Device therapy for ventricular arrhythmias requires careful patient selection and understanding of device-drug interactions, with future devices expected to combine pacing, cardioversion, and defibrillation capabilities.
May inform device decisions in ventricular arrhythmia patients; leaves open prospective trials on integrated multi-function devices.
Device therapy is becoming increasingly important in the management of patients with life-threatening ventricular arrhythmias. Currently, antitachycardia pacemakers and endovascular cardioverters are available on an experimental basis, while the AICD is commercially available. Although the first two devices are much easier to implant, their use is limited by their potential to accelerate a tachycardia or cause it to degenerate to ventricular fibrillation, and their lack of backup high energy defibrillation capabilities. The majority of patients receiving antitachycardia devices will require concomitant antiarrhythmic therapy and all three devices have unique interactions with such drugs. Extensive evaluation and careful preimplantation patient selection are essential if device therapy is to be successful. The antitachycardia device of the future, however, will be easily implantable and much more sophisticated, combining features of all three of these devices as well as the increased flexibility provided by extensive programming and telemetry capabilities.
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Lynda E. Rosenfeld (1988) conducted a review in Life-threatening ventricular arrhythmias. Device therapy (antitachycardia pacemakers, endovascular cardioverters, AICD) was evaluated. Device therapy for life-threatening ventricular arrhythmias requires careful patient selection and often necessitates concomitant antiarrhythmic therapy.
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