Key result
FLOSEAL is linked to a ~21% lower likelihood of exceeding expected hospital length of stay.
Why the study?
Does FLOSEAL reduce the likelihood of exceeding expected hospital length of stay compared to other hemostatic agents in patients undergoing cardiac procedures?
Cohort (n=36,950)
Yes
Does FLOSEAL reduce the likelihood of exceeding expected hospital length of stay compared to other hemostatic agents in patients undergoing cardiac procedures?
Odds Ratio: 0.791
p-value: p=<.01
FLOSEAL may reduce hospital length of stay in patients undergoing cardiac surgery compared to other hemostatic agents.
May reduce prolonged stays after cardiac procedures; leaves open superiority versus other agents in randomized trials.
Hemostatic agents (HAs) are efficacious in reducing blood loss during surgery, which may affect postoperative length of stay (LOS). The purpose of this study was to compare the expected and actual LOS by HA in cardiac procedures. Hospital claims data between 2003 and 2006 were extracted from a US service-level comparative database. Four cohorts for comparison were FLOSEAL, SURGICEL + thrombin, GELFOAM + thrombin, and other. Expected LOS was derived using 2006 Centers for Medicare and Medicaid LOS by diagnosis-related group, and 2-part regression models were created to assess outcome. A total of 36 950 discharges were included. FLOSEAL was associated with less likelihood of exceeding expected LOS compared with baseline (odds ratio = 0.791; P < .01). Among patients who did exceed expected LOS, FLOSEAL patients did so at a reduced rate (incidence rate ratio = 0.891; P < .01). Further assessment is warranted to distinguish products with favorable outcomes.
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Krishnan et al. (2009) conducted a cohort in Cardiovascular surgery (n=36,950). FLOSEAL vs. SURGICEL + thrombin, GELFOAM + thrombin, and other was evaluated on Likelihood of exceeding expected length of stay (LOS) (OR 0.791, p=<.01). FLOSEAL use in cardiac procedures was associated with a lower likelihood of exceeding expected hospital length of stay compared with baseline (OR 0.791; P < 0.01).
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