Simultaneous Determination of 19 Chlorophenols in Water by Liquid Chromatography‐Mass Spectrometry with Solid‐Phase Extraction

A method to simultaneously determinate 19 chlorophenols (CPs) in water by liquid chromatography, coupled with atmospheric pressure chemical ionization mass spectrometry (LC‐APCI‐MS), and a solid‐phase extraction utilizing Oasis® HLB cartridges to preconcentrate the target analytes was developed. The method was linear in the range 0.5∼25.0 µg/L with a good correlation coefficient (r>0.996) for all CPs. The limits of detection (LODs) were 0.4∼30.0 ng/L, extraction recoveries were 87.5∼100.4%, intra‐day RSDs were 5∼12%, and inter‐day RSDs were 7∼15%. This method has been successfully applied to the analysis of water samples. In addition, a comparison was obtained between APCI‐MS and ESI‐MS for the determination of the 19 CPs.