We have designed new double stimuli-responsive polyelectrolyte microcapsules to be useable under physiological conditions to handle biomacromolecules while avoiding the risk of denaturation. They are made of poly(4-vinylpyridine hydrochloride) (PVP) and poly(sodium styrene sulfonate) (PSS). The microcontainers are sensitive to temperature variation, as they irreversibly shrink under heating. In addition, the capsules reversibly swell at pH > 6, making it possible to encapsulate human serum proteins by diffusion through the polymer membrane. Encapsulation efficiency is quantified by fluorescence techniques.
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Basset et al. (2010) studied this question.
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