Key result
Male sex is linked to ~35% higher ischemic stroke prevalence than female sex.
Why the study?
What are the independent risk factors for ischemic stroke in older men and women in a geriatrics practice?
Observational (n=1,911)
No
What are the independent risk factors for ischemic stroke in older men and women in a geriatrics practice?
Age, hypertension, diabetes, and LDL cholesterol are significant independent risk factors for ischemic stroke in older men and women, with smoking and low HDL adding risk in women.
Answers are grounded in this paper and cite their sources.
May support hypertension control in older adults of both sexes; leaves open whether sex-specific strategies improve outcomes.
We performed a retrospective analysis of charts investigating risk factors for ischemic stroke in 467 men (mean age 80±8 years) and 1444 women (mean age 81±8 years) seen in an academic geriatrics practice. Ischemic stroke was present in 126 of 467 men (27%) and in 296 of 1444 women (20%) (p=0.003). Stepwise logistic regression analysis showed that significant independent risk factors for ischemic stroke were age (p=0.005 in men and 0.010 in women, odds ratio=1.04 in men and 1.03 in women); cigarette smoking (p=0.006, odds ratio=1.7 in women); hypertension (p<0.001 in men and women, odds ratio=4.6 in men and 3.9 in women); diabetes mellitus (p=0.018 in men and <0.001 in women, odds ratio=1.9 in men and 2.0 in women); serum low-density lipoprotein cholesterol (p<0.001 in men and women, odds ratio=1.02 in men and 1.01 in women); and serum high-density lipoprotein cholesterol (p<0.001, odds ratio=0.97 in women). Significant independent risk factors for ischemic stroke in both sexes were: age, hypertension, diabetes mellitus, and serum low-density cholesterol; and in older women: cigarette smoking and serum high-density lipoprotein cholesterol (inverse association).
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Ness et al. (2000) conducted an observational in Ischemic stroke (n=1,911). Male sex and cardiovascular risk factors vs. Female sex and absence of risk factors was evaluated on Ischemic stroke (p=0.003). Ischemic stroke was more prevalent in men than women (27% vs 20%, p=0.003), with hypertension being a strong independent risk factor in both sexes (OR 4.6 in men, 3.9 in women).
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