Monolayer‐Barcoded Nanoparticles for On‐Chip DNA Hybridization Assay

The Da Vinci Code: Monolayer-barcoded nanoparticles have been successfully prepared by simultaneous incorporation of probe elements and organic molecules. The organic species serve as mass-tagging surrogates for MS readout and allow on-chip DNA hybridization assay by laser desorption/ionization time-of-flight MS. The strategy could readily be extended to the identification of a vast range of biomolecular binding events.