Key result
ALDH-bright cell levels correlate closely with traditional EPC markers and decline with worsening CAD.
Why the study?
Accurate assessment of circulating endothelial progenitor cells is of significant interest, yet current assays have limitations.
Does an assay based on ALDH activity reliably identify circulating progenitor cells compared to standard cell surface markers in patients undergoing cardiac catheterization?
Cross-Sectional (n=110)
Does an assay based on ALDH activity reliably identify circulating progenitor cells compared to standard cell surface markers in patients undergoing cardiac catheterization?
Effect estimate: r = 0.72
p-value: p=<0.001
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Aldehyde dehydrogenase activity provides a simplified and reliable method for quantifying circulating endogenous progenitor cells, which correlate inversely with age and coronary disease severity.
Povsic et al. (2007) conducted a cross-sectional in Coronary artery disease (n=110). Aldehyde dehydrogenase (ALDH) activity assay vs. CD133+CD34+ cell surface expression was evaluated on Correlation of ALDH-bright cells with CD133+CD34+ cells (r = 0.72, p=<0.001). Aldehyde dehydrogenase-bright cells correlated closely with CD133+CD34+ cells (r = 0.72; p < 0.001) and were inversely associated with patient age and coronary disease severity.
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