Key result
E-cigarette exposure alters adrenal cortex histology and biochemical markers, which improve after withdrawal.
Why the study?
To assess structural changes in the adrenal cortex of adult male albino rats exposed to electronic cigarettes and explore the effect of withdrawal.
Does electronic cigarette exposure cause structural changes in the adrenal cortex of adult male albino rats, and does withdrawal improve these changes?
Does electronic cigarette exposure cause structural changes in the adrenal cortex of adult male albino rats, and does withdrawal improve these changes?
Electronic cigarette exposure induces reversible histopathological and biochemical damage to the adrenal cortex in a rat model.
Answers are grounded in this paper and cite their sources.
E-cigarette exposure may alter rat adrenal cortex; leaves open human relevance and any clinical implications.
Electronic cigarettes, also known as "cigs," are gadgets created to provide nicotine through a vaping solution rather than smoke and without the burning of tobacco. E-cigarettes are aggressively promoted as consumables among people who want to live healthier lives and are seen as a safer alternative to cigarettes. Aim: To assess structural changes in the adrenal cortex of adult male albino rats and explore effect of withdrawal of electronic cigarette.30 adult male rats weighting 150-230 g which were purchased from the Animal house of the faculty of medicine, Zagazig University. The animals will be divided equally into 3groups. Each one contains 10 rats as follows: Group (1): (control group); which contain ten rats that will be exposed to fresh air for 28 days to measure normal basic parameters. Group (II): (E- cig treated group); which contain ten rats that will be exposed to 1ml/day of E- liquid containing 18 mg/ml Nicotine For consecutive 5 days/ week for 28 days. Group (III): (withdrawal group); which contain ten rats which will be exposed to 1ml/day of E- liquid containing 18 mg/ml Nicotine For 5 consecutive days/ week for 4 weeks and then will be left without exposure for another 4 weeks. E-cigarette has hazardous effects on adrenal gland cortex histological structure. Also, there were significant increase in adrenal gland weight and the three zones thickness with elevation of MDA level & reduction of SOD level and also increased the level of cortisol and aldosterone in the group treated with E-cig. Moreover, Caspase 3, COX II immune-expression percent area and the number of CD44 +ve cells were significantly increased in treated group. Exposure of adult male albino rats to E-cigs caused histopathological alterations in the adrenal cortex structure with great improvement in its histological structure and biochemical activity after its withdrawal.
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Agaga et al. (2023) studied this question. Electronic cigarette exposure vs. Fresh air was evaluated on Structural changes in the adrenal cortex and biochemical activity. Exposure to electronic cigarettes caused histopathological alterations in the adrenal cortex and altered biochemical markers, which improved after withdrawal.
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