Key result
Prebypass pH ≤7.25 is linked to ~300% higher early mortality after Type A dissection repair.
Why the study?
Malperfusion is a key limiting factor in acute Type A aortic dissection, prompting investigation into preoperative metabolic acidosis thresholds that could influence decision-making.
Does a prebypass pH ≤ 7.25 predict early mortality in patients undergoing surgery for acute Type A aortic dissection?
Cohort (n=153)
No
Does a prebypass pH ≤ 7.25 predict early mortality in patients undergoing surgery for acute Type A aortic dissection?
Hazard Ratio: 4 (95% CI 1.64–9.75)
Absolute Event Rate: 65.7% vs 22%
p-value: p=<0.01
A prebypass pH ≤ 7.25 is a strong independent predictor of early mortality in patients undergoing acute Type A aortic dissection repair, suggesting these high-risk patients might benefit from a two-stage approach.
No takes yet. Share an insight, caveat, or question.
Prebypass acidosis may aid risk stratification; hypothesis-generating for alternative strategies pending prospective validation.
Feier et al. (2019) conducted a cohort in Acute Type A aortic dissection (n=153). Prebypass pH ≤ 7.25 vs. Prebypass pH > 7.25 was evaluated on Early death (<30 days) (HR 4.00, 95% CI 1.64-9.75, p=<0.01). A prebypass pH ≤ 7.25 was associated with a significantly higher risk of early mortality after acute Type A aortic dissection repair (65.7% vs. 22%, HR 4.00).
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: