Key result
Novel iPSC line successfully generated from a patient with FLNC-variant restrictive cardiomyopathy.
The generation of the FAMRCi016-A iPSC line provides a cellular model for studying the pathogenic mechanisms of the FLNC Ala1186Val variant in restrictive cardiomyopathy.
Offers iPSC model for FLNC Ala1186Val cardiomyopathy research; hypothesis-generating and should not yet change practice.
Induced pluripotent stem cell (iPSC) line FAMRCi016-A was generated by reprogramming peripheral blood mononuclear cells (PBMCs) from a patient with the genetic variant FLNC:c.3557C>T p.(Ala1186Val). The iPSC cell line was characterized according to the general standards: the cells had a typical morphology, a normal karyotype (46,XY), expressed pluripotent cell markers (OCT4, NANOG, SOX2, SSEA4), and demonstrated the ability to produce derivatives of three germ layers by directed differentiation. The iPSC line FAMRCi016-A can be used in studies investigating the pathogenic genetic variant FLNC Ala1186Val.
No takes yet. Share an insight, caveat, or question.
Nikitina et al. (2026) studied Restrictive cardiomyopathy (n=1). Generation of induced pluripotent stem cell line FAMRCi016-A was evaluated on Characterization of iPSC line. An induced pluripotent stem cell line (FAMRCi016-A) was successfully generated from a patient with restrictive cardiomyopathy carrying the FLNC Ala1186Val variant and demonstrated pluripotency.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: