Key result
Combined oral estradiol and norethisterone fails to alter carotid and uterine artery pulsatility index versus placebo.
Why the study?
Does continuous combined oral estradiol and norethisterone alter the pulsatility index in internal carotid and uterine arteries in healthy early postmenopausal women?
RCT (n=40)
Randomized
Does continuous combined oral estradiol and norethisterone alter the pulsatility index in internal carotid and uterine arteries in healthy early postmenopausal women?
Short-term continuous combined hormone therapy does not negatively impact vascular resistance in early postmenopausal women, supporting its cardiovascular safety when initiated near menopause.
Supports short-term combined HT safety near menopause without raising vascular resistance; extends RCT evidence on arterial effects in early postmenopausal women.
OBJECTIVE: This study analyzed whether continuous combined oral estradiol and norethisterone had any effect on the pulsatility index (PI) of the internal carotid and uterine arteries in Taiwanese early postmenopausal women. MATERIALS AND METHODS: A group of 40 healthy postmenopausal women with no history of hormone therapy (HT) participated in this study and were randomly subdivided into two groups: HT treatment group (n = 20) and placebo group (n = 20). PI was evaluated with color Doppler ultrasound at the beginning of the study and after 4 months of HT (2 mg 17beta-estradiol + 1 mg norethisterone acetate) or placebo. RESULTS: There was no significant change in the PI of the internal carotid and the uterine arteries after 4 months of HT. CONCLUSION: This HT regimen showed no significant negative impact on vascular resistance in Taiwanese early postmenopausal women. Results are compatible with the updated recommendations on HT stating that there is little cardiovascular risk when HT is initiated within a few years of the menopause.
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Huang et al. (2009) conducted an RCT in Early postmenopausal (n=40). Continuous combined oral estradiol and norethisterone vs. Placebo was evaluated on Pulsatility index of the internal carotid and uterine arteries. Continuous combined oral estradiol and norethisterone for 4 months resulted in no significant change in the pulsatility index of internal carotid and uterine arteries compared to placebo.
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