Fast atom bombardment mass spectra of the bis-guanosine adduct with cisplatin

Cisplatin, cis-Pt(NH3)2Cl2, is used as an anticancer drug. In the present work, we show that fast atom bombardment mass spectrometry is a useful technique in the structural investigation of a complex containing one molecule of cisplatin and two guanosine molecules. Elemental composition and structures of characteristic ions have been postulated and confirmed by direct isotopic analysis, by the study of their collisional induced dissociation and their metastable spectra. Thus, fast atom bombardment mass spectrometry seems to be a useful tool for the characterization of platinum-nucleosides adducts.