Ischemic Colitis Associated with Factor V Leiden Mutation

Letters4 April 2000Ischemic Colitis Associated with Factor V Leiden MutationNelson S. Yee, MD, PhD, DuPont Guerry IV, MD, and Gary R. Lichtenstein, MDNelson S. Yee, MD, PhDUniversity of Pennsylvania School of Medicine; Philadelphia, PA 19104-4283 (Yee)University of Pennsylvania School of Medicine; Philadelphia, PA 19104-4283 (Guerry)University of Pennsylvania School of Medicine; Philadelphia, PA 19104-4283 (Lichtenstein), DuPont Guerry IV, MDUniversity of Pennsylvania School of Medicine; Philadelphia, PA 19104-4283 (Yee)University of Pennsylvania School of Medicine; Philadelphia, PA 19104-4283 (Guerry)University of Pennsylvania School of Medicine; Philadelphia, PA 19104-4283 (Lichtenstein), and Gary R. Lichtenstein, MDUniversity of Pennsylvania School of Medicine; Philadelphia, PA 19104-4283 (Yee)University of Pennsylvania School of Medicine; Philadelphia, PA 19104-4283 (Guerry)University of Pennsylvania School of Medicine; Philadelphia, PA 19104-4283 (Lichtenstein)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-7-200004040-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Ischemic colitis in young adults is often associated with hypercoagulable states that result in thrombotic occlusion of small vessels supplying the colon. Inherited thrombophilia due to deficiency of protein C, protein S, and antithrombin III, as well as acquired resistance to activated protein C and use of oral contraceptives, are risk factors for ischemic colitis (1, 2). We report a case of ischemic colitis in a woman who used oral contraceptives and had the factor V Leiden mutation.A 24-year-old woman who had used oral contraceptives for 6 years and had no history of cigarette smoking or ...References1. Gandhi SK, Hanson MM, Vernava AM, Kaminski DL, Longo WE. Ischemic colitis. Dis Colon Retum. 1996;39:88-100. CrossrefMedlineGoogle Scholar2. Mann DE, Kessel ER, Mullins DL, Lottenberg R. Ischemic colitis and acquired resistance to activated protein C in a woman using oral contraceptives. Am J Gastroenterol. 1998;93:1960-2. CrossrefMedlineGoogle Scholar3. Deana DG, Dean PJ. Reversible ischemic colitis in young women. Association with oral contraceptive use. Am J Surg Pathol. 1995;19:454-62. CrossrefMedlineGoogle Scholar4. Vandenbroucke JP, Koster T, Briet E, Reitsma PH, Bertina RM, Rosendaal FR. Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation. Lancet. 1994;344:1453-57. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania School of Medicine; Philadelphia, PA 19104-4283 (Yee)University of Pennsylvania School of Medicine; Philadelphia, PA 19104-4283 (Guerry)University of Pennsylvania School of Medicine; Philadelphia, PA 19104-4283 (Lichtenstein) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEndoscopic mucosal biopsy – histopathological interpretationCOLONIC ISCHAEMIA AND ISCHAEMIC COLITISIschemic colitis: Clinical practice in diagnosis and treatmentA case of ischemic colitis associated with factor V Leiden mutation: successful treatment with anticoagulationColite ischémiqueThe epidemiology of ischaemic colitisRole of acquired and hereditary thrombotic risk factors in colon ischemia of ambulatory patients 4 April 2000Volume 132, Issue 7Page: 595-596KeywordsColitisColonFactor V LeidenOral contraceptive therapyPlasma proteinsProtein C deficiencyProtein S deficiencyThrombosisUltrasound imagingYoung adults Issue Published: 4 April 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...