Clinical factors associated with days to hCG remission with low risk gestational trophoblastic neoplasia

This is the authors' abstract. We don't add key points for this paper.

Objective: To assess the effect of clinical factors on time to hCG remission and chemo-resistance among women with low risk gestational trophoblastic neoplasia (GTN).Methods: This retrospective study compromised of 69 patients diagnosed with low risk GTN.Associations of time to hCG remission with various factors were investigated using odds ratio.Associations of chemo-resistance with above clinical variables were analysed using chi square test.Results: The analysis showed that FIGO score >4, hCG > 10 4 mIU/mL at diagnosis, and need for second line multiagent therapy were associated with statistically significant increased days to remission.For every increase in stage there was increase in days to remission by approximately 17 days.For every one unit increase in FIGO score there was increase of remission by approximately 4 days.Serum hCG > 10000 mIU/mL was associated with the risk of chemo-resistance.Conclusions: FIGO score > 4, pre-treatment serum hCG > 10,000 mIU/mL is associated with the risk of chemo-resistance.Prompt identification of risk factors and change of chemotherapy to minimize the exposure of these patients to ineffective chemotherapy is essential.This decreases the morbidity, toxicity and treatment time in these young patients.