Key result
Larger Ellipsoid Max semi-axis linked to intracranial aneurysm rupture risk.
Why the study?
This study evaluated the connection between the risk of aneurysm rupture and three geometrical features (Ellipsoid Max semi-axis, Size ratio, and Tortuosity) using computational fluid dynamics and hemodynamic analysis.
Do specific morphology parameters (Ellipsoid Max semi-axis, Size ratio, Tortuosity) correlate with the risk of rupture in intracranial aneurysms?
Case-Control (n=30)
Do specific morphology parameters (Ellipsoid Max semi-axis, Size ratio, Tortuosity) correlate with the risk of rupture in intracranial aneurysms?
Computational fluid dynamics and statistical analysis suggest that the Ellipsoid Max semi-axis is a meaningful morphological predictor of intracranial aneurysm rupture risk.
Ellipsoid Max semi-axis may aid rupture risk stratification; hypothesis-generating and requires prospective validation before clinical use.
The hemodynamic analysis of the blood stream inside the cerebral aneurysms reveals the risk of the aneurysm rupture. In addition, the high risk region prone to rupture would be determined by the hemodynamic analysis of the blood. In present article, computational fluid dynamic is used for the investigation of the hemodynamic effects on the aneurysm wall and risk of rupture. This study tries to find the connection between the risk of rupture with three geometrical features of aneurysm i.e., Ellipsoid Max semi-axis, Size ratio and Tortuosity. Statistical analysis is done over 30 different ruptured /unruptured ICA aneurysms to find meaningful relation between selected geometrical factors and rupture risk. The hemodynamic analysis is done over four distinct aneurysm models to attain more details on effects of chosen geometrical factors. The results of simulations indicate that the Ellipsoid Max semi-axis have meaningful impacts on the risk of rupture.
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Wang et al. (2023) conducted a case-control in Intracranial aneurysms (n=30). Ellipsoid Max semi-axis vs. Unruptured aneurysms was evaluated on Average Ellipsoid Max semi-axis (p=0.004). The average Ellipsoid Max semi-axis was significantly higher in ruptured intracranial aneurysms compared to unruptured ones (4.634 vs 3.225, p=0.004), indicating a direct connection with rupture risk.
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