SYNOPSIS It a hole is cut through the ear of a rabbit it will fill in by the comergent growth of new tissue from around the margins Centimeter wide holes are usually obliterated in 6 to 8 weeks The regenerated tissues include newly differentiated cartilage and occasional tufts of hair To determine the specificity of skin in this kind of growth that on both sides of the eai was replaced by grafts of belly sVin When holes were subsequently punched through the transplant regions limited regeneration ensued but no new cartilage was produced If sheets of cartilage were removed fiom poitions of rabbit eais and the resultant aieas perforated through the remaining two layers of skin no regeneration whatever occurred Not even the missing cartilage gieu back These remits indicate that replacement of the ciitilaginous sheet requnes the proximity of a healing wound in the oveilying ear skin, ind that skin from clscwhcie on the body canno' support its regeneiation
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Goss et al. (1972) studied this question.