Background and objective This study aims to investigate the association between exercise tolerance, pulmonary function and lower‐limb muscle function in patients with lung cancer who underwent lung resection surgery in the previous year. Methods Sixty‐four patients (age: 67 ± 11 years, 66% males) performed a symptom‐limited incremental cycle test to define peak oxygen consumption (VO2peak) and peak workload (Wpeak). The best of two 6‐min walking distance (6MWD) tests was also included. Isometric quadriceps strength and isokinetic quadriceps endurance were measured. Post‐bronchodilator spirometry, lung volumes and diffusing capacity of the lung for carbon monoxide (DLCO) measurements were assessed. Univariate correlation analysis and multiple regression analyses were performed. Results VO2peak, W peak and6MWDshowed moderate to strong correlations with quadriceps strength/endurance andDLCOwhile weak to moderate correlations were found with forced expiratory volume in 1 s (FEV1), functional residual capacity (FRC) and body weight. Multiple regression showed that peak isometric quadriceps strength (P < 0.001) andDLCO(P < 0.001) were significant predictors ofVO2peak (explained varianceR2 = 0.67), while quadriceps endurance (P = 0.0015) andDLCO(P < 0.0001) were significant predictors of W peak (R2 = 0.61). Quadriceps endurance capacity (P = 0.013), but notDLCO, significantly contributed to the6MWDmodel (R2 = 0.29). Conclusion We identified a strong significant relationship between peak aerobic capacity and quadriceps muscle function and lung diffusing capacity.6MWDwas significantly related to quadriceps muscle function but not to pulmonary function. These findings suggest that accurate assessment of lower‐limb muscle strength has a role in the accurate interpretation of exercise tests and in selecting optimal candidates for resistance training interventions targeting the lower‐limb muscles after resection surgery.
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Burtin et al. (2017) studied this question.