Key result
Levetiracetam linked to torsades de pointes and cardiac arrest via prolonged QTc, hypokalemia, and hypomagnesemia.
Why the study?
Levetiracetam has a favorable safety profile, and torsades de pointes or cardiac arrest following its administration is exceptionally rare.
Case Report (n=1)
No
Levetiracetam can rarely induce severe QTc prolongation, torsades de pointes, and cardiac arrest, highlighting the need for electrolyte and EKG monitoring in susceptible patients.
Answers are grounded in this paper and cite their sources.
Rare levetiracetam-associated torsades warrants vigilance; single case leaves causal link hypothesis-generating.
Torsades de pointes occurs in the presence of a prolonged QTc interval, which has many congenital and acquired causes. Levetiracetam is a widely used anti-epileptic medication secondary to its favorable safety profile. We present a rare case of a 59-year-old male who developed torsades de pointes and cardiac arrest after levetiracetam administration. To our knowledge, there is only one other case report documenting torsades de pointes after levetiracetam administration, and our case report will be the first documenting cardiac arrest after levetiracetam administration.
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Mann et al. (2023) conducted a case report in Seizure disorder (n=1). Levetiracetam was evaluated on Torsades de pointes and cardiac arrest. Levetiracetam administration in a 59-year-old male induced hypokalemia, hypomagnesemia, and a prolonged QTc interval, resulting in torsades de pointes and cardiac arrest.
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