One-pot Synthesis of 3-Methyl-4-arylmethylene-isoxazol-5(4H)-ones Catalyzed by Sodium Benzoate in Aqueous Media: A Green Chemistry Strategy

recently been discovered to be a powerful method for the synthesis of structurally diverse chemical libraries of drug-like heterocyclic compounds, since the products are formed in a single step and diversity can be achieved by simply varying each component.1 The search and discovery for new MCRs on one hand, and the full exploitation of the already known multicomponent reactions on the other hand, is therefore of considerable current interest.2 One such MCR that belongs to the latter category is the isoxazol-5(4H)-ones derivatives synthesis.3 Isoxazole derivatives have attracted increasing interest due to their significant pharmaceutical and therapeutic properties, such as hypoglycemic, immunosuppressive, anti-inflammatory, and anti-bacterial activity.4 In addition, iso-xazole derivatives have served as a versatile building block