Solid-Supported Benzotriazoles. 2. Synthetic Auxiliaries and Traceless Linkers for the Combinatorial Synthesis of Unsymmetrical Ureas

Resin-bound benzotriazole chemistry applied to the solid-phase synthesis of arrays of unsymmetrical aryl ureas is described here. The chemistry assessment process, the monomer rehearsal, the preparation of a discrete library by automated parallel synthesis, the parallel purification protocol employing solid-phase scavenging, and the complete analytical characterization of the library components are also presented.