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January 1, 1987Synthesis

Nickel-Catalyzed Synthesis of Arylacetonitriles from Arylzinc Chlorides and Bromoacetonitrile

Torbjörn Frejd Tomas Klingstedt

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Abstract

All articles of this category Arylacetonitriles are synthesised by coupling arylzinc chlorides with bromoacetonitrile using Ni(acac) 2 /P( c -C 6 H 11 )(C 6 H 5 ) 2 as catalyst. The arylacetonitriles are reduced in situ with LiAlH 4 /AlCl 3 to give the corresponding 2-aryl-1-aminoethanes

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Frejd et al. (1987) studied this question.

synapsesocial.com/papers/6aa8accf754fc2a1eb2772b3 https://doi.org/10.1055/s-1987-27834

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