Effects of the intravenous application of sodium ascorbate in patients with the diagnosis of sepsis in the intensive care unit – observational, analytical, retrospective, comparative study

OBJECTIVES: To evaluate whether high-dose intravenous sodium ascorbate improves inflammatory markers in patients with sepsis. METHODS: A retrospective, observational, analytical, and comparative study was conducted on patients diagnosed with sepsis and admitted to the ICU at Clínica Estrios (Cartagena, Colombia) between July 1 and 30, 2024. Patients receiving standard treatment were compared with those who also received high-dose intravenous sodium ascorbate (>462 mg/kg/day), supplied by Biological Therapies, Australia. The main outcome was the duration of altered SIRS and SOFA scores. RESULTS: =9.00, p=0.003) compared to those who received standard therapy. CONCLUSIONS: High-dose sodium ascorbate may serve as an effective adjuvant therapy in sepsis.