The use of solid phase microextraction for quantitative analysis of methadone in urine is reported. The proposed procedure allows the extraction of methadone from a urine matrix, avoiding sample handling and saving evaporation of solvents and concentration steps. A fiber coated with polymethylsiloxane was employed for the extraction of methadone from urine and subsequently directly injected into the GUMS apparatus. Specific and reproducible results were obtained with high sensitivity.
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Chiarotti et al. (1994) studied this question.
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