Diagnosis of Vulvovaginal Candidiasis and Effectiveness of Combined Topical Treatment with Nystatin: Results of a Non-Interventional Study in 973 Patients

Introduction & Objectives: This non-interventional study was performed in 231 gynaecological surgeries in order to assess current routine diagnostic practice as well as present effectiveness and tolerability of a combined topical treatment with nystatin in patients with uncomplicated vulvovaginal candidiasis (VVC).Methods: Naïve or insufficiently treated VVC patients received a combined topical antimycotic treatment § .Diagnostic procedures were documented.Cardinal disease symptoms and dosage regimens were recorded before and after therapy.Investigators and patients rated treatment effectiveness and tolerance.Adverse events and withdrawals were documented.Results: All 1,011case reports were included in the safety analysis; thereof 973 cases in the efficacy analysis.Based on diagnoses conform to guidelines 74.7% of the patients had a primary infection while 24.9% were experiencing a relapse.After a treatment period of 6 days (median), individual symptoms had ceased in up to 81.9%.Complete healing was achieved in 63.1% (vulva) and 65.4% (vagina).Investigators rated therapy outcome as "healing/significant improvement" in 90.0%(vulva) and 88.2% (vagina), and tolerance "as very good/good" in 97.4%.Conclusions: Routine diagnosis of VVC predominantly corresponds to relevant guidelines.Combined intra-and perivaginal therapy of VVC with nystatin is an effective, safe and cost-conscious treatment option.Nystatin has not lost its effectiveness over the years.§ Nystatin cream and vaginal tablets (Biofanal ® 100.000IU combination package), Dr.