Key result
Periaortic leptin antagonist prevents aortic root enlargement in a Marfan syndrome mouse model.
Why the study?
Given de novo leptin synthesis in ascending aortic aneurysm walls of patients with Marfan syndrome, researchers tested whether local counteracting of leptin activity prevents aortic cardiovascular complications.
Does periaortic application of low-dose leptin antagonist prevent aortic root dilatation and preserve left ventricular systolic function in a murine model of Marfan syndrome?
Population
Fbn1 C1039G/+ mice
Comparison
Periaortic application of low-dose leptin antagonist at the aortic root vs saline
Design
Murine animal model study
Authors
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Hypothesis-generating for leptin antagonism in Marfan aortopathy; human trials needed before clinical adoption.
Does periaortic application of low-dose leptin antagonist prevent aortic root dilatation and preserve left ventricular systolic function in a murine model of Marfan syndrome?
p-value: p=<0.001
Local periaortic application of a leptin antagonist prevents aortic root dilatation and preserves left ventricular systolic function in a Marfan syndrome mouse model, suggesting a potential novel therapeutic approach.
Fisch et al. (2020) studied Marfan syndrome. Periaortic application of leptin antagonist vs. Saline was evaluated on Increase in aortic root diameter (p=<0.001). Local, periaortic application of a low-dose leptin antagonist prevented the increase in aortic root diameter in a mouse model of Marfan syndrome (P<0.001).
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