How to respond to abnormal liver function tests Clinical clue Disease Alcohol abuse (overt/covert) Alcoholic liver disease Increased body mass index Non-alcoholic steatohepatitis Non-insulin dependent diabetes mellitus Previous intravenous drug use Chronic hepatitis C or B Non-sterile needle use (eg war service) Chronic hepatitis C Blood transfusion prior to 1990 Recent new drugs or herbal remedies Drug-induced hepatotoxicity Family history of liver disease Haemochromatosis Wilson's disease History of other autoimmune disease Primary biliary cirrhosis Autoimmune hepatitis Recent travel to developing nations Acute hepatitis A or E Diarrhoea Primary sclerosing cholangitis
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Collier et al. (2002) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: