Key result
Bariatric surgery reduces carotid inflammation in morbidly obese patients to control levels at 1 year.
Why the study?
The molecular imaging markers correlating with reduction of cardiovascular events after bariatric surgery in morbidly obese patients were not fully characterized.
Does bariatric surgery reduce carotid artery inflammation and alter metabolic activity in adipose tissues in morbidly obese patients?
Cohort (n=10)
Does bariatric surgery reduce carotid artery inflammation and alter metabolic activity in adipose tissues in morbidly obese patients?
Bariatric surgery normalizes carotid artery inflammation and beneficially impacts metabolic activity in various adipose tissues, providing a potential mechanism for reduced cardiovascular events.
In this study, we unravel a molecular imaging marker correlated with the known reduction of cardiovascular events (most commonly related to vulnerable plaques) in morbidly obese patients after bariatric surgery (BaS).We prospectively imaged 10 morbidly obese subjects with F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography before and 1 year after BaS. F-FDG uptake-which is enhanced in inflamed, atherosclerotic vessels and in metabolically active adipose tissues-was quantified in the carotids, pericardial adipose tissue (PAT), visceral adipose tissue (VAT), as well as brown adipose tissue (BAT). The degree of carotid inflammation was compared to lean and overweight controls.Carotid inflammation significantly declined leading to an F-FDG uptake comparable to the 2 control groups. Metabolic activity significantly decreased in PAT and VAT and increased in BAT.BaS leads to a normalization of carotid artery inflammation and a beneficial impact on the metabolic activity in PAT, VAT, and BAT that is related to the metabolic syndrome observed in this patient group.
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Bucerius et al. (2015) conducted a cohort in Morbid obesity (n=10). Bariatric surgery vs. Baseline and lean/overweight controls was evaluated on F-FDG uptake in carotids, pericardial adipose tissue, visceral adipose tissue, and brown adipose tissue.
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